Security :: Iptables Requirement \ Package Passed Through Masquerade Don't Pass Through The Prerouting Rule?

The iptables has every rule set correctly, the users in the subnet works great, but I have the following issue.every user connect to a mysql running on the internet through the port 3306, the forward and masquerade do the job. Now I have a user in the outside, and he wants to connect to a mysql in a certain machine (Not the gateway), prerouting rules solve my problems, but all the packages from the inside users goes now to that certain machine. I would like something like if the package passed trough masquerade don't pass trough the prerouting rule, and if it come from the outside (Not a package that come from a petition from the inside) pass trough the prerouting rule.